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Close-up of Bubble Up Pizza Casserole showing the stretchy mozzarella cheese and charred pepperoni edges.

Bubble Up Pizza Casserole: The Easiest Weeknight Pepperoni Bake

This Bubble Up Pizza Casserole features puffed golden biscuit chunks, thick red sauce, and melted mozzarella. Topped with crispy charred pepperoni and dried herbs, it's a 30-minute family favorite that perfectly satisfies every pizza craving.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 6 people
Course: Dinner, Lunch
Cuisine: American, Italian-American
Calories: 385
Ingredients Equipment Method Notes

Ingredients
  

Casserole Components
  • 16 oz (450g) Refrigerated biscuit dough Cut into quarters
  • 1.5 cups (350ml) Pizza sauce Thick and vibrant red
  • 2 cups (225g) Mozzarella cheese Shredded, whole milk preferred
  • 4 oz (115g) Pepperoni slices Thin circular slices
  • 1 tsp Dried oregano
  • 1 tsp Dried basil

Equipment

  • 1 9x13 inch white rectangular ceramic baking dish
  • 1 Large Mixing Bowl
  • 1 Kitchen shears or knife

Method
 

Preparation
  1. Preheat oven to 375°F (190°C). Grease a 9x13 inch ceramic baking dish. Cut each biscuit into 4 pieces.
  2. In a bowl, toss biscuit pieces with 1 cup of pizza sauce until fully coated. Spread evenly in the baking dish.
Assembling and Baking
  1. Drizzle the remaining sauce over the biscuits. Top with mozzarella and pepperoni slices.
  2. Bake for 25-30 minutes until biscuits are golden-brown and cheese features toasted spots. Pepperoni should be crispy and curled.
  3. Remove from oven, sprinkle with dried oregano and basil. Let rest 5 minutes before serving.

Notes

For extra crispiness, broil for 1 minute at the end.
Freshly shredded cheese melts much better than bagged varieties.